Analysis of Trichophyton rubrum gene expression in response to cytotoxic drugs.

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Paiao FG, Segato F, Cursino-Santos JR, Peres NT, Martinez-Rossi NM

Analysis of Trichophyton rubrum gene expression in response to cytotoxic drugs.

FEMS Microbiol Lett. 2007 Jun;271(2):180-6. doi: 10.1111/j.1574-6968.2007.00710.x. Epub 2007 Apr 10.

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17425668 [ View in PubMed

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Abstract

Suppressive subtractive hybridization was used to isolate transcripts specifically upregulated during Trichophyton rubrum exposure to acriflavin, fluconazole, griseofulvin, terbinafine or undecanoic acid. Macro-array dot-blot and sequencing of 132 clones, which correspond to genes differentially expressed after exposition of T. rubrum to at least one of these cytotoxic drugs, revealed 39 unique genes. Of these, 32 have not been previously described in T. rubrum, representing an increase in the number of T. rubrum genes that have been identified. The upregulation of the novel genes encoding a retrotransposon element, a carboxylic ester hydrolase, a copper resistance-associated P-type ATPase, a DNA mismatch repair protein and a NIMA (never in mitosis A) interactive protein was confirmed by Northern blot.

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Polypeptides

Name	UniProt ID
ABC multidrug transporter MDR2	A0A059JJ46	Details