Synthetic inhibitors of trypsin, plasmin, kallikrein, thrombin, C1r-, and C1 esterase.
Article Details
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Tamura Y, Hirado M, Okamura K, Minato Y, Fujii S
Synthetic inhibitors of trypsin, plasmin, kallikrein, thrombin, C1r-, and C1 esterase.
Biochim Biophys Acta. 1977 Oct 13;484(2):417-22.
- PubMed ID
- 143965 [ View in PubMed]
- Abstract
p-Carbethoxyphenyl episol-guanidinocaproate and p-(p'-guanidinobenzoyloxy)-phenyl derivatives were prepared, and their inhibitory effects on trypsin, plasmin, plasma kallikrein, thrombin, C1r- and C1 esterase were examined. Among the various inhibitors tested, p-nitrophenyl p'-guanidinobenzoate, N,N-dimethylamino p-(p'-guanidinobenzoyloxy)-benzoyl glycolate and N,N-dimethylamino p-(p'-guanidinobenzoyloxy)-benzilcarbonyloxy glycolate were the most effective inhibitors of trypsin, plasmin, plasma kallikrien and thrombin, and they strongly inhibited the esterolytic activities of C1r- and C1 esterase.
DrugBank Data that Cites this Article
- Drugs
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Camostat Trypsin-1 Protein Humans UnknownInhibitorDetails Gabexate Plasma kallikrein Protein Humans YesInhibitorDetails Gabexate Plasminogen Protein Humans YesInhibitorDetails Gabexate Prothrombin Protein Humans YesInhibitorDetails - Drug Enzymes
Drug Enzyme Kind Organism Pharmacological Action Actions Gabexate Complement C1r subcomponent Protein Humans NoInhibitorDetails Gabexate Complement C1s subcomponent Protein Humans NoInhibitorDetails Gabexate Trypsin-1 Protein Humans NoInhibitorDetails