Point mutations in the dihydrofolate reductase-thymidylate synthase gene and pyrimethamine and cycloguanil resistance in Plasmodium falciparum.

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Basco LK, Eldin de Pecoulas P, Wilson CM, Le Bras J, Mazabraud A

Point mutations in the dihydrofolate reductase-thymidylate synthase gene and pyrimethamine and cycloguanil resistance in Plasmodium falciparum.

Mol Biochem Parasitol. 1995 Jan;69(1):135-8. doi: 10.1016/0166-6851(94)00207-4.

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7723784 [ View in PubMed

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DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Proguanil	Bifunctional dihydrofolate reductase-thymidylate synthase	Protein	Plasmodium falciparum (isolate K1 / Thailand)	Unknown	Inhibitor	Details