Central role of the P2Y12 receptor in platelet activation.

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Dorsam RT, Kunapuli SP

Central role of the P2Y12 receptor in platelet activation.

J Clin Invest. 2004 Feb;113(3):340-5. doi: 10.1172/JCI20986.

PubMed ID
14755328 [ View in PubMed
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Abstract

Platelet activation occurs in response to vessel injury and is important for the arrest of bleeding. Platelet activation during disease states leads to vascular occlusion and ischemic damage. The P2Y(12) receptor, activated by ADP, plays a central role in platelet activation and is the target of P2Y(12) receptor antagonists that have proven therapeutic value.

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