Targeting protein prenylation in progeria.

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Young SG, Yang SH, Davies BS, Jung HJ, Fong LG

Targeting protein prenylation in progeria.

Sci Transl Med. 2013 Feb 6;5(171):171ps3. doi: 10.1126/scitranslmed.3005229.

PubMed ID
23390246 [ View in PubMed
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Abstract

A clinical trial of a protein farnesyltransferase inhibitor (lonafarnib) for the treatment of Hutchinson-Gilford progeria syndrome (HGPS) was recently completed. Here, we discuss the mutation that causes HGPS, the rationale for inhibiting protein farnesyltransferase, the potential limitations of this therapeutic approach, and new potential strategies for treating the disease.

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