In Vitro Resistance and Evolution of Resistance to Tavaborole in Trichophyton rubrum.

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Mazzantini D, Celandroni F, Calvigioni M, Lupetti A, Ghelardi E

In Vitro Resistance and Evolution of Resistance to Tavaborole in Trichophyton rubrum.

Antimicrob Agents Chemother. 2021 Mar 18;65(4):e02324-20. doi: 10.1128/AAC.02324-20. Print 2021 Mar 18.

PubMed ID

33468466 [ View in PubMed

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Abstract

Tavaborole is currently used in the topical treatment of onychomycosis. In this study, we analyzed the in vitro emergence/evolution of resistance against tavaborole in Trichophyton rubrum When T. rubrum strains were propagated on media containing the MIC of tavaborole, spontaneous resistant mutants were isolated at a frequency of 10(-8) The frequency was almost 100-fold higher following fungal growth in the presence of a subinhibitory tavaborole concentration (0.5-fold the MIC) for 10 transfers. All collected mutants showed similar 4- to 8-fold increases in the drug MIC. No cross-resistance to other antifungals was evident.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Tavaborole	leucine--tRNA ligase	Protein	Trichophyton rubrum	Yes	Inhibitor	Details