(S)-9-(2,3-Dihydroxypropyl)adenine: An Aliphatic Nucleoside Analog with Broad-Spectrum Antiviral Activity.

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DE Clercq E, Descamps J, DE Somer P, Holyacute A

(S)-9-(2,3-Dihydroxypropyl)adenine: An Aliphatic Nucleoside Analog with Broad-Spectrum Antiviral Activity.

Science. 1978 May 5;200(4341):563-5. doi: 10.1126/science.200.4341.563.

PubMed ID

17839440 [ View in PubMed

]

Abstract

(S)-9-(2,3-Dihydroxypropyl)adenine, a novel nucleoside analog, the sugar moiety of which is replaced by an aliphatic chain, inhibits the replication in vitro of several DNA and RNA viruses, including vaccinia, herpes simplex (types 1 and 2), measles, and vesicular stomatitis. It is also effective in vivo in reducing the mortality rate of mice inoculated intranasally with vesicular stomatitis virus.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
S-9-(2-hydroxypropyl)adenine	Adenosine deaminase	Protein	Humans	Unknown	Inhibitor	Details
S-9-(2-hydroxypropyl)adenine	Thymidine kinase	Protein	Human herpesvirus 1 (strain KOS)	Unknown	Inducer	Details