1-[(Benzofuran-2-yl)phenylmethyl]-triazoles and -tetrazoles - potent competitive inhibitors of aromatase.
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Vinh TK, Ahmadi M, Delgado PO, Perez SF, Walters HM, Smith HJ, Nicholls PJ, Simons C
1-[(Benzofuran-2-yl)phenylmethyl]-triazoles and -tetrazoles - potent competitive inhibitors of aromatase.
Bioorg Med Chem Lett. 1999 Jul 19;9(14):2105-8.
- PubMed ID
- 10450990 [ View in PubMed]
- Abstract
The synthesis of a series of novel 1-[(benzofuran-2-yl)phenylmethyl]-triazoles and -tetrazoles is described. The compounds were tested for human placental aromatase inhibition in vitro, using [1beta-3H]-androstenedione as the substrate for the aromatase enzyme, the percentage inhibition and IC50 data is included.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Aminoglutethimide Cytochrome P450 19A1 IC 50 (nM) 18500 N/A N/A Details