Benzothieno[3,2-b]indole derivatives as potent selective estrogen receptor modulators.
Article Details
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Ji Q, Gao J, Wang J, Yang C, Hui X, Yan X, Wu X, Xie Y, Wang MW
Benzothieno[3,2-b]indole derivatives as potent selective estrogen receptor modulators.
Bioorg Med Chem Lett. 2005 Jun 2;15(11):2891-3.
- PubMed ID
- 15911274 [ View in PubMed]
- Abstract
A series of estrogen receptor ligands based on benzothieno[3,2-b]indole were synthesized and their binding affinity for estrogen receptor subtypes (ERalpha and ERbeta) and effects on mouse uterus and bone were evaluated. Some of these compounds showed strong binding affinity to ER and significantly increased the bone mineral density of ovariectomized mice.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Raloxifene Estrogen receptor alpha IC 50 (nM) 0.89 N/A N/A Details Raloxifene Estrogen receptor beta IC 50 (nM) 1.6 N/A N/A Details