3-[2-(Pyrrolidin-1-yl)ethyl]indoles and 3-[3-(piperidin-1-yl)propyl]indoles: agonists for the h5-HT1D receptor with high selectivity over the h5-HT1B subtype.
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Castro JL, Street LJ, Guiblin AR, Jelley RA, Russell MG, Sternfeld F, Beer MS, Stanton JA, Matassa VG
3-[2-(Pyrrolidin-1-yl)ethyl]indoles and 3-[3-(piperidin-1-yl)propyl]indoles: agonists for the h5-HT1D receptor with high selectivity over the h5-HT1B subtype.
J Med Chem. 1997 Oct 24;40(22):3497-500.
- PubMed ID
- 9357514 [ View in PubMed]
- Abstract
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DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Rizatriptan 5-hydroxytryptamine receptor 1B IC 50 (nM) 41 N/A N/A Details Rizatriptan 5-hydroxytryptamine receptor 1D EC 50 (nM) 8.4 N/A N/A Details Rizatriptan 5-hydroxytryptamine receptor 1D IC 50 (nM) 11 N/A N/A Details Sumatriptan 5-hydroxytryptamine receptor 1B IC 50 (nM) 16 N/A N/A Details Sumatriptan 5-hydroxytryptamine receptor 1D EC 50 (nM) 16 N/A N/A Details Sumatriptan 5-hydroxytryptamine receptor 1D IC 50 (nM) 5 N/A N/A Details