Isoaurostatin, a novel topoisomerase inhibitor produced by Thermomonospora alba.
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Suzuki K, Yahara S, Maehata K, Uyeda M
Isoaurostatin, a novel topoisomerase inhibitor produced by Thermomonospora alba.
J Nat Prod. 2001 Feb;64(2):204-7.
- PubMed ID
- 11430001 [ View in PubMed]
- Abstract
A novel inhibitor of topoisomerase I designated as isoaurostatin (1) was isolated from the culture filtrate of Thermomonospora alba strain No. 1520. The structure of 1 was determined to be 6,4'-dihydroxyisoaurone on the basis of spectroscopic (NMR and MS) methods. Compound 1 inhibited the relaxation activity of calf thymus topoisomerase I in a noncompetitive manner and did not inhibit the relaxation and decatenation of human placenta topoisomerase II. Compound 1 is an inhibitor belonging to cleavable complex-nonforming type without DNA intercalation.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Camptothecin DNA topoisomerase 1 IC 50 (nM) 4000 N/A N/A Details Camptothecin DNA topoisomerase 1 IC 50 (nM) 17000 N/A N/A Details Camptothecin DNA topoisomerase 1 IC 50 (nM) 9000 N/A N/A Details Doxorubicin DNA topoisomerase 2-alpha IC 50 (nM) 1000 N/A N/A Details