Novel guanidine-based inhibitors of inosine monophosphate dehydrogenase.
Article Details
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Iwanowicz EJ, Watterson SH, Liu C, Gu HH, Mitt T, Leftheris K, Barrish JC, Fleener CA, Rouleau K, Sherbina NZ, Hollenbaugh DL
Novel guanidine-based inhibitors of inosine monophosphate dehydrogenase.
Bioorg Med Chem Lett. 2002 Oct 21;12(20):2931-4.
- PubMed ID
- 12270177 [ View in PubMed]
- Abstract
A series of novel guanidine-based small molecule inhibitors of inosine monophosphate dehydrogenase (IMPDH) was explored. IMPDH catalyzes the rate determining step in guanine nucleotide biosynthesis and is a target for anticancer, immunosuppressive and antiviral therapy. The synthesis and the structure-activity relationships (SARs), derived from in vitro studies, for this new series of inhibitors is given.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Mycophenolic acid Inosine-5'-monophosphate dehydrogenase 2 IC 50 (nM) 15 N/A N/A Details