Novel inhibitors of IMPDH: a highly potent and selective quinolone-based series.
Article Details
- CitationCopy to clipboard
Watterson SH, Carlsen M, Dhar TG, Shen Z, Pitts WJ, Guo J, Gu HH, Norris D, Chorba J, Chen P, Cheney D, Witmer M, Fleener CA, Rouleau K, Townsend R, Hollenbaugh DL, Iwanowicz EJ
Novel inhibitors of IMPDH: a highly potent and selective quinolone-based series.
Bioorg Med Chem Lett. 2003 Feb 10;13(3):543-6.
- PubMed ID
- 12565968 [ View in PubMed]
- Abstract
A series of novel quinolone-based small molecule inhibitors of inosine monophosphate dehydrogenase (IMPDH) was explored. The synthesis and the structure-activity relationships (SARs) derived from in vitro studies are described.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Mycophenolic acid Inosine-5'-monophosphate dehydrogenase 1 IC 50 (nM) 55 N/A N/A Details Mycophenolic acid Inosine-5'-monophosphate dehydrogenase 2 IC 50 (nM) 14 N/A N/A Details