Design, synthesis, and in vitro biological activity of indole-based factor Xa inhibitors.
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Arnaiz DO, Zhao Z, Liang A, Trinh L, Witlow M, Koovakkat SK, Shaw KJ
Design, synthesis, and in vitro biological activity of indole-based factor Xa inhibitors.
Bioorg Med Chem Lett. 2000 May 1;10(9):957-61.
- PubMed ID
- 10853668 [ View in PubMed]
- Abstract
A series of indole and carbazole based inhibitors of factor Xa (FXa) has been investigated. The most potent compound inhibits FXa with a Ki of 0.2 nM and has 900- and 750-fold selectivity over thrombin and trypsin, respectively.