Discovery and parallel synthesis of a new class of cathepsin K inhibitors.
Article Details
- CitationCopy to clipboard
Smith RA, Bhargava A, Browe C, Chen J, Dumas J, Hatoum-Mokdad H, Romero R
Discovery and parallel synthesis of a new class of cathepsin K inhibitors.
Bioorg Med Chem Lett. 2001 Nov 19;11(22):2951-4.
- PubMed ID
- 11677133 [ View in PubMed]
- Abstract
Peptidomimetic aminomethyl ketones have been identified as a new class of cathepsin K inhibitors. Traditional and high-speed parallel synthesis techniques were applied to investigate this series. Structure-activity relationships were established, and certain analogues were characterized with IC(50) values in the range 200-500 nM.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) N2-[(Benzyloxy)carbonyl]-N-[(3R)-1-{N-[(benzyloxy)carbonyl]-L-leucyl}-4-oxo-3-pyrrolidinyl]-L-leucinamide Cathepsin K Ki (nM) 2 N/A N/A Details