Time-dependent inactivation of human phenylethanolamine N-methyltransferase by 7-isothiocyanatotetrahydroisoquinoline.
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Wu Q, Caine JM, Thomson SA, Slavica M, Grunewald GL, McLeish MJ
Time-dependent inactivation of human phenylethanolamine N-methyltransferase by 7-isothiocyanatotetrahydroisoquinoline.
Bioorg Med Chem Lett. 2009 Feb 15;19(4):1071-4. doi: 10.1016/j.bmcl.2009.01.014. Epub 2009 Jan 10.
- PubMed ID
- 19171483 [ View in PubMed]
- Abstract
Inhibitors of phenylethanolamine N-methyltransferase [PNMT, the enzyme that catalyzes the final step in the biosynthesis of epinephrine (Epi)] may be of use in determining the role of Epi in the central nervous system. Here we describe the synthesis and characterization of 7-SCN tetrahydroisoquinoline as an affinity label for human PNMT.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) 1,2,3,4-Tetrahydro-Isoquinoline-7-Sulfonic Acid Amide Phenylethanolamine N-methyltransferase Ki (nM) 120 N/A N/A Details