Asymmetric synthesis of BB-3497--a potent peptide deformylase inhibitor.
Article Details
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Pratt LM, Beckett RP, Davies SJ, Launchbury SB, Miller A, Spavold ZM, Todd RS, Whittaker M
Asymmetric synthesis of BB-3497--a potent peptide deformylase inhibitor.
Bioorg Med Chem Lett. 2001 Oct 8;11(19):2585-8.
- PubMed ID
- 11551755 [ View in PubMed]
- Abstract
By screening a library of metalloenzyme inhibitors, the N-formyl-hydroxylamine derivative BB-3497 was identified as a potent inhibitor of Escherichia coli peptide deformylase with antibacterial activity both in vitro and in vivo. The homochiral synthesis of BB-3497, involving a novel asymmetric Michael addition reaction is described.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) 2-[(Formyl-Hydroxy-Amino)-Methyl]-Heptanoic Acid [1-(2-Hydroxymethyl-Pyrrolidine-1-Carbonyl)-2-Methyl-Propyl]-Amide Peptide deformylase, mitochondrial IC 50 (nM) 10 N/A N/A Details Bb-3497 Peptide deformylase, mitochondrial IC 50 (nM) 70 N/A N/A Details Bb-3497 Peptide deformylase, mitochondrial IC 50 (nM) 7 N/A N/A Details