Synthesis and PDF inhibitory activities of novel benzothiazolylidenehydroxamic acid derivatives.

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Takayama W, Shirasaki Y, Sakai Y, Nakajima E, Fujita S, Sakamoto-Mizutani K, Inoue J

Synthesis and PDF inhibitory activities of novel benzothiazolylidenehydroxamic acid derivatives.

Bioorg Med Chem Lett. 2003 Oct 6;13(19):3273-6.

PubMed ID

12951107 [ View in PubMed

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Abstract

A novel series of benzothiazolylidenehydroxamic acid derivatives has been designed and synthesized as PDF inhibitors. Some of this novel class of PDF inhibitors exhibited micromolar order enzyme inhibitory activity and antibacterial activity.

DrugBank Data that Cites this Article

Binding Properties

Drug	Target	Property	Measurement	pH	Temperature (°C)
2-[(Formyl-Hydroxy-Amino)-Methyl]-Heptanoic Acid [1-(2-Hydroxymethyl-Pyrrolidine-1-Carbonyl)-2-Methyl-Propyl]-Amide	Peptide deformylase, mitochondrial	IC 50 (nM)	1.5	N/A	N/A	Details
2-[(Formyl-Hydroxy-Amino)-Methyl]-Heptanoic Acid [1-(2-Hydroxymethyl-Pyrrolidine-1-Carbonyl)-2-Methyl-Propyl]-Amide	Peptide deformylase, mitochondrial	Ki (nM)	0.3	N/A	N/A	Details