Through the "gatekeeper door": exploiting the active kinase conformation.
Article Details
- CitationCopy to clipboard
Zuccotto F, Ardini E, Casale E, Angiolini M
Through the "gatekeeper door": exploiting the active kinase conformation.
J Med Chem. 2010 Apr 8;53(7):2681-94. doi: 10.1021/jm901443h.
- PubMed ID
- 20000735 [ View in PubMed]
- Abstract
Not Available
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) N-cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide Vascular endothelial growth factor receptor 2 IC 50 (nM) 0.6 N/A N/A Details Purvalanol A Proto-oncogene tyrosine-protein kinase Src IC 50 (nM) 240 N/A N/A Details