Viridin analogs derived from steroidal building blocks.
Article Details
- CitationCopy to clipboard
Viswanathan K, Ononye SN, Cooper HD, Kyle Hadden M, Anderson AC, Wright DL
Viridin analogs derived from steroidal building blocks.
Bioorg Med Chem Lett. 2012 Nov 15;22(22):6919-22. doi: 10.1016/j.bmcl.2012.09.015. Epub 2012 Sep 13.
- PubMed ID
- 23040731 [ View in PubMed]
- Abstract
Naturally occurring furanosteroids such as viridin and wortmannin have long been known as potent inhibitors of the lipid kinase PI-3K. We have been interested in directly accessing analogs of these complex natural products from abundant steroid feedstock materials. In this communication, we describe the synthesis of viridin/wortmannin hybrid molecules from readily available building blocks that function as PI-3K inhibitors and maintain their electrophilic properties. The compounds also show anti-proliferative effects against a breast cancer line.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Wortmannin Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform IC 50 (nM) 11.9 N/A N/A Details