The discovery of new spirocyclic muscarinic M3 antagonists.
Article Details
- CitationCopy to clipboard
Stocks MJ, Alcaraz L, Bailey A, Bowers K, Donald D, Edwards H, Hunt F, Kindon N, Pairaudeau G, Theaker J, Warner DJ
The discovery of new spirocyclic muscarinic M3 antagonists.
Bioorg Med Chem Lett. 2010 Dec 15;20(24):7458-61. doi: 10.1016/j.bmcl.2010.10.016. Epub 2010 Oct 28.
- PubMed ID
- 21036043 [ View in PubMed]
- Abstract
The optimisation of a new series of high potency muscarinic M3 antagonists, derived from high throughput screening library hit is described.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Aclidinium Muscarinic acetylcholine receptor M1 IC 50 (nM) 0.1 N/A N/A Details Aclidinium Muscarinic acetylcholine receptor M2 IC 50 (nM) 0.126 N/A N/A Details Aclidinium Muscarinic acetylcholine receptor M3 IC 50 (nM) 0.126 N/A N/A Details Aclidinium Muscarinic acetylcholine receptor M4 IC 50 (nM) 0.2 N/A N/A Details Aclidinium Muscarinic acetylcholine receptor M5 IC 50 (nM) 0.158 N/A N/A Details