Adeno-associated virus vector integration.
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Deyle DR, Russell DW
Adeno-associated virus vector integration.
Curr Opin Mol Ther. 2009 Aug;11(4):442-7.
- PubMed ID
- 19649989 [ View in PubMed]
- Abstract
Adeno-associated virus (AAV) vectors efficiently transduce various cell types and can produce long-term expression of transgenes in vivo. Although AAV vector genomes can persist within cells as episomes, vector integration has been observed in various experimental settings, either at non-homologous sites where DNA damage may have occurred or by homologous recombination. In some cases, integration is essential for the therapeutic or experimental efficacy of AAV vectors. Recently, insertional mutagenesis resulting from the integration of AAV vectors was associated with tumorigenesis in mice, a consideration that may have relevance for certain clinical applications.
DrugBank Data that Cites this Article
- Drugs
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Voretigene neparvovec Retinoid isomerohydrolase Protein Humans YesGene replacementDetails