Pharmacokinetics of alpha-dihydroergokryptine in monkeys after oral administration.
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Grognet JM, Istin M, Zanotti A, Mailland F, Coppi G
Pharmacokinetics of alpha-dihydroergokryptine in monkeys after oral administration.
Drugs Exp Clin Res. 1991;17(6):309-12.
- PubMed ID
- 1769319 [ View in PubMed]
- Abstract
The pharmacokinetic profile of a single dose (6 mg/kg) of alpha-dihydroergokryptine (alpha-DHEK) was established after oral administration in monkeys using a radio-immunoassay technique for non-metabolized drug. alpha-DHEK showed a plasma profile according to an open three-compartment pharmacokinetic model with a long half-life (mean = 5.787 h). The disposition of alpha-DHEK involves a fast absorption, a slow distribution phase and a slow elimination phase. alpha-DHEK showed an high total clearance and distribution volume; the drug is largely metabolized, as concluded from the very low urinary excretion.
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