Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes.
Article Details
- CitationCopy to clipboard
Ullrich A, Bell JR, Chen EY, Herrera R, Petruzzelli LM, Dull TJ, Gray A, Coussens L, Liao YC, Tsubokawa M, et al.
Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes.
Nature. 1985 Feb 28-Mar 6;313(6005):756-61.
- PubMed ID
- 2983222 [ View in PubMed]
- Abstract
We have deduced the entire 1,370-amino-acid sequence of the human insulin receptor precursor from a single complementary DNA clone. The precursor starts with a 27-amino-acid signal sequence, followed by the receptor alpha-subunit, a precursor processing enzyme cleavage site, then the beta-subunit containing a single 23-amino-acid transmembrane sequence. There are sequence homologies to human epidermal growth factor receptor and the members of the src family of oncogene products.