Directed pharmacological therapy of ambiguous genitalia due to an androgen receptor gene mutation.
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Ong YC, Wong HB, Adaikan G, Yong EL
Directed pharmacological therapy of ambiguous genitalia due to an androgen receptor gene mutation.
Lancet. 1999 Oct 23;354(9188):1444-5.
- PubMed ID
- 10543676 [ View in PubMed]
- Abstract
We report a 46,XY infant with an M807T mutation in his androgen receptor that abrogated cellular responses to testosterone, but not to dihydrotestosterone (DHT), resulting in ambiguous genitalia. Treatment with a topical DHT gel restored male genital development allowing the infant to be reared in accordance with his chromosomal sex.