An interferon-induced protein with release factor activity is a tryptophanyl-tRNA synthetase.
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Bange FC, Flohr T, Buwitt U, Bottger EC
An interferon-induced protein with release factor activity is a tryptophanyl-tRNA synthetase.
FEBS Lett. 1992 Mar 30;300(2):162-6.
- PubMed ID
- 1373391 [ View in PubMed]
- Abstract
Interferon gamma induces expression of a protein termed IFP 53 according to its molecular weight of 53 kDa. IFP 53 shows significant sequence homology to rabbit peptide chain release factor as well as to bovine tryptophanyl-tRNA synthetase. IFP 53 has been shown to possess release factor activity for the UGA stop codon. We demonstrate here, by using a recombinant IFP 53 fusion protein, that IFP 53 tryptophanylates tRNA. These data indicate that IFP 53 is a protein with two activities: peptide chain termination and aminoacylation.