Adamantane sulfone and sulfonamide 11-beta-HSD1 Inhibitors.
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Sorensen B, Winn M, Rohde J, Shuai Q, Wang J, Fung S, Monzon K, Chiou W, Stolarik D, Imade H, Pan L, Deng X, Chovan L, Longenecker K, Judge R, Qin W, Brune M, Camp H, Frevert EU, Jacobson P, Link JT
Adamantane sulfone and sulfonamide 11-beta-HSD1 Inhibitors.
Bioorg Med Chem Lett. 2007 Jan 15;17(2):527-32. Epub 2006 Oct 7.
- PubMed ID
- 17070044 [ View in PubMed]
- Abstract
Potent and selective adamantane sulfone and sulfonamide inhibitors of 11-beta-HSD-1 have been discovered. Selected compounds from these series have robust pharmacokinetic profiles and strongly inhibit liver, fat, and brain HSD1 for extended periods after oral dosing.