Detection of a gamma-carboxy-glutamate as novel post-translational modification of human transthyretin.
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Ruggeberg S, Horn P, Li X, Vajkoczy P, Franz T
Detection of a gamma-carboxy-glutamate as novel post-translational modification of human transthyretin.
Protein Pept Lett. 2008;15(1):43-6.
- PubMed ID
- 18221012 [ View in PubMed]
- Abstract
During analysis of the proteome in the cerebrospinal fluid (CSF) of the Caucasian form of moyamoya disease (MMD), a novel post-translational modification of human transthyretin was observed. Two-dimensional electrophoresis and subsequent peptide sequencing with ESI-MS/MS were performed to discover the gamma-carboxylation of the Glu-42 (Gla-42).