Diverse polymorphism within a short coding region of the human aldehyde dehydrogenase-5 (ALDH5) gene.
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Sherman D, Dave V, Hsu LC, Peters TJ, Yoshida A
Diverse polymorphism within a short coding region of the human aldehyde dehydrogenase-5 (ALDH5) gene.
Hum Genet. 1993 Nov;92(5):477-80.
- PubMed ID
- 8244338 [ View in PubMed]
- Abstract
Human aldehyde dehydrogenase-5 gene (originally named as ALDHX) is expressed in liver and testis. The ALDH5 does not contain introns in the coding sequence for 517 amino acid residues. Within a short nucleotide region of the gene, the following three nucleotide changes were found in high frequencies, i.e., a silent C<-->T at nucleotide (nt) 183, C<-->T at nt 257 associated with a Val<-->Ala substitution, and T<-->G at nt 320 associated with a Arg<-->Leu substitution. The frequency of C at nt 183 is 81% in Caucasians and 65% in Japanese, and the difference is statistically not significant. The frequency of C at nt 257 is 76% in Caucasians and 55% in Japanese, and the difference is statistically significant (P = 0.02). The frequency of T at nt 320 is 71% in Caucasians, while it is only 27% in Japanese. The racial difference at nt 320 is highly significant (P < 0.001). No significant difference was found in the genotypes of the three nucleotide positions between alcoholic and nonalcoholic Caucasians within the limited numbers of subjects examined.