The nucleotide sequence of human aminoacylase-1.
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Mitta M, Kato I, Tsunasawa S
The nucleotide sequence of human aminoacylase-1.
Biochim Biophys Acta. 1993 Aug 19;1174(2):201-3.
- PubMed ID
- 8357837 [ View in PubMed]
- Abstract
The nucleotide sequence of a cDNA coding for human aminoacylase-1 (N-acylamino acid aminohydrolase, ACY-1, EC 3.5.1.14) subunit has been determined. The amino acid sequence of human ACY-1 subunit deduced from its cDNA nucleotide sequence showed a high degree of identity (87.7%) with the corresponding protein from porcine [1], although the former is one amino acid residue longer than the latter. Of 12 histidine and 3 cysteine residues, conserved between the proteins from two species, some are anticipated to form the active site of ACY-1 as either catalytic residues or ligands for an essential Zn2+ atom.