Amino acid sequence of human protein Z, a vitamin K-dependent plasma glycoprotein.
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Ichinose A, Takeya H, Espling E, Iwanaga S, Kisiel W, Davie EW
Amino acid sequence of human protein Z, a vitamin K-dependent plasma glycoprotein.
Biochem Biophys Res Commun. 1990 Nov 15;172(3):1139-44.
- PubMed ID
- 2244898 [ View in PubMed]
- Abstract
Protein Z is a vitamin K-dependent glycoprotein isolated and characterized from human and bovine plasma. A cDNA coding for human protein Z has been obtained by the isolation of phage clones from a liver cDNA library and in vitro amplification of two other liver libraries. Protein Z is synthesized with a prepro-leader sequence of 40 amino acids. The mature protein is composed of 360 residues including a Gla domain of 13 carboxyglutamic acid residues, two epidermal growth factor domains, and a carboxyl terminal region which is highly homologous to the catalytic domain of serine proteases. Human protein Z, however, contains an Asp instead of Ser and a Lys instead of His in the catalytic triad of the active site.