Molecular cloning and sequencing of human palmitoyl-CoA ligase and its tissue specific expression.
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Ghosh B, Barbosa E, Singh I
Molecular cloning and sequencing of human palmitoyl-CoA ligase and its tissue specific expression.
Mol Cell Biochem. 1995 Oct 4;151(1):77-81.
- PubMed ID
- 8584017 [ View in PubMed]
- Abstract
A complimentary DNA clone encoding the entire human palmitoyl-CoA ligase has been isolated from a liver cDNA library and sequenced in it's entirety. The predicted product is a 699 amino acid protein. Southern analysis utilizing the human palmitoyl-CoA ligase gene as a probe revealed varying degrees of similarity amongst various mammalian species. The palmitoyl-CoA ligase gene is highly expressed in liver, heart, skeletal muscle and kidney, and to a lesser extent in brain, lung, placenta and pancreas. The expression of palmitoyl-CoA ligase in various tissue parallels the function of this enzyme in the metabolism of fatty acids in these tissues.