A common motif of two adjacent phosphoserines in bovine, rabbit and human cardiac troponin I.
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Mittmann K, Jaquet K, Heilmeyer LM Jr
A common motif of two adjacent phosphoserines in bovine, rabbit and human cardiac troponin I.
FEBS Lett. 1990 Oct 29;273(1-2):41-5.
- PubMed ID
- 2226863 [ View in PubMed]
- Abstract
From rabbit and human cardiac troponin I N-terminal mono and bisphosphorylated peptides were isolated which were obtained from Lys-C proteinase digests. Two adjacent phosphoserine residues could be localized in each phosphopeptide following further tryptic digestion. The previously published sequence of rabbit cardiac troponin I had to be corrected. Two adjacent phosphoserine residues are a common motif in the very similar sequences of bovine, rabbit and human cardiac troponin I. The N-terminal sequences are: AcADRSGGSTAG DTVPAPPPVR RRS(P)S(P)ANYRAY ATEPHAK (bovine), AcADESTDA-AG EARPAPAPVR RRS(P)S(P)ANYRAY ATEPHAK (rabbit), (Ac,A,D/N,G,S,S,D/N,A,A,R) EPRPAPAPIR RRS(P)S(P)-NYRAY ATEPHAK (human).