Nucleotide and deduced amino acid sequence of human cysteinyl-tRNA synthetase.
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Cruzen ME, Arfin SM
Nucleotide and deduced amino acid sequence of human cysteinyl-tRNA synthetase.
DNA Seq. 1994;4(4):243-8.
- PubMed ID
- 7987009 [ View in PubMed]
- Abstract
We have determined the nucleotide sequence of a cDNA coding human cysteinyl-tRNA synthetase. The predicted protein sequence of 638 amino acids has substantial sequence similarity to the E. coli cysteinyl-tRNA synthetase in the nucleotide-binding fold region that constitutes the potential active site. The results are consistent with the hypothesis that evolution of the full complement of aminoacyl-tRNA synthetases occurred prior to the divergence of prokaryotes and eukaryotes.