A new member of the plasma protease inhibitor gene family.
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Ragg H
A new member of the plasma protease inhibitor gene family.
Nucleic Acids Res. 1986 Jan 24;14(2):1073-88.
- PubMed ID
- 3003690 [ View in PubMed]
- Abstract
A 2.1-kb cDNA clone representing a new member of the protease inhibitor family was isolated from a human liver cDNA library. The inhibitor, named human Leuserpin 2 (hLS2), comprises 480 amino acids and contains a leucine residue at its putative reactive center. HLS2 is about 25-28% homologous to three human members of the plasma protease inhibitor family: antithrombin III, alpha 1-antitrypsin and alpha 1-antichymotrypsin. A comparison with published partial amino acid sequences shows that hLS2 is closely related to the thrombin inhibitor heparin cofactor II.