Structure and expression of the gene coding for the human serpin hLS2.
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Ragg H, Preibisch G
Structure and expression of the gene coding for the human serpin hLS2.
J Biol Chem. 1988 Aug 25;263(24):12129-34.
- PubMed ID
- 2841345 [ View in PubMed]
- Abstract
We have analyzed genomic clones encoding human leuserpin 2 (hLS2). The gene covers about 14.5 kilobases and consists of 5 exons and 4 introns. The genes coding for hLS2, alpha 1-antitrypsin, alpha 1-antichymotrypsin, and rat angiotensinogen share an equivalent exon-intron structure and therefore constitute a distinct subgroup within the serpin gene family, which otherwise displays a highly variable exon-intron pattern. With the exception of a segment in the second exon, the sequence similarity of the genes coding for hLS2 and alpha 1-antitrypsin extends to all exons including one encoding the 5'-untranslated sequences. The implications of these findings with respect to the genesis of the amino-terminal heterogeneity in the serpin family are discussed.