Quinazolinedione sulfonamides: a novel class of competitive AMPA receptor antagonists with oral activity.
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Koller M, Lingenhoehl K, Schmutz M, Vranesic IT, Kallen J, Auberson YP, Carcache DA, Mattes H, Ofner S, Orain D, Urwyler S
Quinazolinedione sulfonamides: a novel class of competitive AMPA receptor antagonists with oral activity.
Bioorg Med Chem Lett. 2011 Jun 1;21(11):3358-61. doi: 10.1016/j.bmcl.2011.04.017. Epub 2011 Apr 8.
- PubMed ID
- 21531559 [ View in PubMed]
- Abstract
Quinazoline-2,4-diones with a sulfonamide group attached to the N(3) ring atom constitute a novel class of competitive AMPA receptor antagonists. One of the synthesized compounds, 28, shows nanomolar receptor affinity, whereas other examples of the series display oral anticonvulsant activity in animal models.