A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes.

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Lee ST, Strunk KM, Spritz RA

A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes.

Oncogene. 1993 Dec;8(12):3403-10.

PubMed ID
8247543 [ View in PubMed
]
Abstract

We have used the reverse transcription-polymerase chain reaction to survey the repertoire of protein tyrosine kinases expressed in cultured normal human melanocytes, a differentiated cell type derived from the neural crest. We identified 25 different tyrosine kinase cDNAs among a total of 608 protein tyrosinase kinase-related cDNAs analyzed. Six encode receptor tyrosine kinases for known ligands, several of which have been implicated in controlling melanocyte proliferation in vitro. Two others encode apparent receptor tyrosine kinases for unknown ligands. Four encode known non-receptor tyrosine kinases and five encode previously identified anonymous protein tyrosine kinases. Of the eight other melanocyte-associated protein tyrosine kinases, most or all appear to be novel. These 25 protein tyrosine kinase genes exhibit distinct patterns of expression in cultured human melanocytes, human erythroleukemia cells, and a variety of normal human tissues. We mapped 16 of the corresponding protein tyrosine kinase genes to specific human chromosomes, identifying a total of 19 human genetic loci, some of which may constitute candidate genes for genetic disorders of mammalian development.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Insulin-like growth factor 1 receptorP08069Details
Hepatocyte growth factor receptorP08581Details
Epithelial discoidin domain-containing receptor 1Q08345Details
Focal adhesion kinase 1Q05397Details
Tyrosine-protein kinase JAK1P23458Details
Tyrosine-protein kinase receptor UFOP30530Details
Tyrosine-protein kinase FerP16591Details