Human neutrophil elastase and cathepsin G cleavage sites in the bait region of alpha 2-macroglobulin. Proposed structural limits of the bait region.
Article Details
- CitationCopy to clipboard
Virca GD, Salvesen GS, Travis J
Human neutrophil elastase and cathepsin G cleavage sites in the bait region of alpha 2-macroglobulin. Proposed structural limits of the bait region.
Hoppe Seylers Z Physiol Chem. 1983 Sep;364(9):1297-302.
- PubMed ID
- 6195065 [ View in PubMed]
- Abstract
The sites of cleavage in the "bait region" of human alpha 2-macroglobulin made by both neutrophil elastase and cathepsin G, as the first step in their inactivation by this inhibitor, have been identified. These positions are at a valylhistidyl bond for elastase and a phenylalanyl-tyrosyl bond for cathepsin G. All of the proteinases tested so far, including those utilized in this study, are cleaving within a twenty-seven aminoacid peptide sequence occurring between two proline residues. It is suggested that this area represents the outer limits of the "bait region" loop.