Coxsackieviruses B1, B3, and B5 use decay accelerating factor as a receptor for cell attachment.
Article Details
- CitationCopy to clipboard
Shafren DR, Bates RC, Agrez MV, Herd RL, Burns GF, Barry RD
Coxsackieviruses B1, B3, and B5 use decay accelerating factor as a receptor for cell attachment.
J Virol. 1995 Jun;69(6):3873-7.
- PubMed ID
- 7538177 [ View in PubMed]
- Abstract
Receptor binding and subsequent cell-mediated internalization or disassembly are the initial steps in virus replication. Cell surface molecules that participate in this process are the primary determinants of virus tissue tropism. Monoclonal antibody blockade, immunoprecipitation, and DNA transfection were used to identify decay accelerating factor as a major cell attachment receptor for coxsackieviruses B1, B3, and B5. However, expression of human decay acceleration factor on the surface of nonpermissive murine fibroblasts led only to virus attachment without subsequent replication, and it was concluded that an additional cellular cofactor(s) is required to facilitate cell entry and subsequent replication.