Human protein S cDNA encodes Phe-16 and Tyr 222 in consensus sequences for the post-translational processing.
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Ploos van Amstel HK, van der Zanden AL, Reitsma PH, Bertina RM
Human protein S cDNA encodes Phe-16 and Tyr 222 in consensus sequences for the post-translational processing.
FEBS Lett. 1987 Sep 28;222(1):186-90.
- PubMed ID
- 2820795 [ View in PubMed]
- Abstract
Partial cDNAs coding for human protein S were isolated from a pUC9 human liver cDNA library. Together, the overlapping clones span a (partial) 5'-non-coding region, and the complete protein S coding and 3'-untranslated regions. The derived amino acid sequence deviates at five positions from two previously reported protein S sequences. Two of these differences (Phe instead of Leu at position -16 and Tyr instead of Asp at position 222) are found in regions that are important for the post-translational modification of protein S, the gamma-carboxylation of glutamic acid and the hydroxylation of asparagine, respectively.