DJ-1 colocalizes with tau inclusions: a link between parkinsonism and dementia.
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Rizzu P, Hinkle DA, Zhukareva V, Bonifati V, Severijnen LA, Martinez D, Ravid R, Kamphorst W, Eberwine JH, Lee VM, Trojanowski JQ, Heutink P
DJ-1 colocalizes with tau inclusions: a link between parkinsonism and dementia.
Ann Neurol. 2004 Jan;55(1):113-8.
- PubMed ID
- 14705119 [ View in PubMed]
- Abstract
Two novel mutations recently have been identified in the DJ-1 gene that cause a new form of autosomal recessive, early-onset parkinsonism. Because the pathological role of this protein is unknown, we examined the issue here and report the colocalization of DJ-1 protein within a subset of pathological tau inclusions in a diverse group of neurodegenerative disorders known as tauopathies. Our study extends the view that different neurodegenerative diseases may have similar pathological mechanisms, and that these processes likely include DJ-1.