Design and synthesis of potent pyridazine inhibitors of p38 MAP kinase.
Article Details
- CitationCopy to clipboard
Tamayo N, Liao L, Goldberg M, Powers D, Tudor YY, Yu V, Wong LM, Henkle B, Middleton S, Syed R, Harvey T, Jang G, Hungate R, Dominguez C
Design and synthesis of potent pyridazine inhibitors of p38 MAP kinase.
Bioorg Med Chem Lett. 2005 May 2;15(9):2409-13.
- PubMed ID
- 15837335 [ View in PubMed]
- Abstract
Novel potent trisubstituted pyridazine inhibitors of p38 MAP (mitogen activated protein) kinase are described that have activity in both cell-based assays of cytokine release and animal models of rheumatoid arthritis. They demonstrated potent inhibition of LPS-induced TNF-alpha production in mice and exhibited good efficacy in the rat collagen induced arthritis model.