Clinical pharmacological studies of tandamine, a potential antidepressive drug.

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Ehsanullah RS, Ghose K, Kirby MJ, Turner P, Witts D

Clinical pharmacological studies of tandamine, a potential antidepressive drug.

Psychopharmacology (Berl). 1977 Mar 23;52(1):73-7.

PubMed ID
403562 [ View in PubMed
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Abstract

Tandamine hydrochloride, a thiopyranoindole, was more active than desmethylimipramine in inhibiting the tyramine pressor response after single oral doses in human volunteers. When compared with a placebo, tandamine was found to possess significant anticholinergic activity, to reduce appetite and to produce sedation. Compared with clomipramine, it caused a smaller inhibition of 5-HT but a more marked inhibition of dopamine uptake into human platelets. Further clinical and pharmacological studies with tandamine may help to elucidate the respective roles of different monoamines in depression, sedation and appetite.

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