The core protein of epican, a heparan sulfate proteoglycan on keratinocytes, is an alternative form of CD44.
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Kugelman LC, Ganguly S, Haggerty JG, Weissman SM, Milstone LM
The core protein of epican, a heparan sulfate proteoglycan on keratinocytes, is an alternative form of CD44.
J Invest Dermatol. 1992 Dec;99(6):886-91.
- PubMed ID
- 1281868 [ View in PubMed]
- Abstract
Epican, a heparan sulfate proteoglycan, was recently identified on the surface of keratinocytes with the aid of a monoclonal antibody to its core protein. Using that antibody to screen a human keratinocyte cDNA library, a clone encoding the entire epican core protein was selected and sequenced. The core protein of epican is a form of CD44. The deduced protein sequence of 699 amino acids has a novel 339 amino acid domain inserted into the proximal extracellular domain of the standard, leukocyte form of CD44. The additional domain adds a number of potential N- and O-linked glycosylation sites and two proteolysis sites to this form of CD44.