Efficacy of decoquinate against Neospora caninum tachyzoites in cell cultures.

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Lindsay DS, Butler JM, Blagburn BL

Efficacy of decoquinate against Neospora caninum tachyzoites in cell cultures.

Vet Parasitol. 1997 Jan;68(1-2):35-40.

PubMed ID
9066049 [ View in PubMed
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Abstract

Neospora caninum is a major cause of abortion in dairy cattle in the United States and other countries. Abortions and neonatal mortality also occur in other ruminant species. Decoquinate is an anticoccidial that is approved for use in cattle and goats in the United States. We studied the efficacy of decoquinate against tachyzoites of N. caninum in a 5-day of treatment, cell culture flask lesion-based assay. Decoquinate killed tachyzoites at concentrations of 0.1 and 0.01 microgram ml-1. Decoquinate had little measurable effect on extracellular tachyzoites. Decoquinate acted quickly to kill intracellular stages at coccidiocidal concentrations; tachyzoites were killed within 5 min at 0.1 microgram ml-1 decoquinate.

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