Characterization of the tissue-specific expression of the s100P gene which encodes an EF-hand Ca2+-binding protein.
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Jin G, Wang S, Hu X, Jing Z, Chen J, Ying K, Xie Y, Mao Y
Characterization of the tissue-specific expression of the s100P gene which encodes an EF-hand Ca2+-binding protein.
Mol Biol Rep. 2003 Dec;30(4):243-8.
- PubMed ID
- 14672411 [ View in PubMed]
- Abstract
S100 proteins are a calcium-binding protein family containing two EF-hand domains exclusively expressed in vertebrates and play roles in many cellular activities. Human S100P gene was first cloned as a 439 bp cDNA in placenta and it was found to be associated with human prostate cancer. Here we describe the cloning of the 1297 bp full-length cDNA, and the characterization of the tissue-specific expression of the human S100P gene. It is abundantly expressed in many tissues including placenta by Northern blot and RT-PCR analysis, unlike the expression pattern of other S100 family genes.