Revision of the amino acid sequence of human heart fatty acid-binding protein.
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Borchers T, Hojrup P, Nielsen SU, Roepstorff P, Spener F, Knudsen J
Revision of the amino acid sequence of human heart fatty acid-binding protein.
Mol Cell Biochem. 1990 Oct 15-Nov 8;98(1-2):127-33.
- PubMed ID
- 2266954 [ View in PubMed]
- Abstract
Cardiac-type fatty acid-binding protein (cFABP) from human heart muscle of three individuals was isolated and characterized as pI 5.3-cFABP. The proteins were structurally analyzed by tryptic peptide mapping, application of plasma desorption time-of-flight mass spectrometry and amino acid sequencing. All three preparations of human heart FABP, having 132 amino acids, differed from the published sequence [Offner et al. Biochem J 251: 191-198, 1988] in position 104, where Leu is found instead of Lys, and in position 124, where Cys is found instead of Ser.