Calcium inhibition of efrotomycin production by Nocardia lactamdurans.

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Cover WH, Kirpekar AC, George H, Stieber RW

Calcium inhibition of efrotomycin production by Nocardia lactamdurans.

J Ind Microbiol. 1991 Jan;7(1):41-4.

PubMed ID
1367205 [ View in PubMed
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Abstract

Efrotomycin is a modified polyketide antibiotic of the elfamycin family that has use in the area of pig husbandry. Optimization of the fermentation medium for production of efrotomycin by Nocardia lactamdurans revealed that the fermentation is sensitive to hard water and certain lots of cottonseed flour used to prepare a complex fermentation medium. A limited metal ion analysis of the hard water indicated that calcium ions are present at concentrations found to be inhibitory by the addition of calcium chloride to medium prepared with distilled water. Similarly, a correlation between lots of cottonseed flour that poorly supported the fermentation and high calcium levels is presented. Further experimentation revealed that by altering the sterilization conditions of the cottonseed flour, the inhibitory effect of poor lots could be prevented.

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