Nucleotide sequence of the Escherichia coli K12 histidine operon revisited.
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Jovanovic G, Kostic T, Jankovic M, Savic DJ
Nucleotide sequence of the Escherichia coli K12 histidine operon revisited.
J Mol Biol. 1994 Jun 10;239(3):433-5.
- PubMed ID
- 8201624 [ View in PubMed]
- Abstract
We report on a significant difference between the published nucleotide sequence of the Escherichia coli K12 histidine operon and our sequencing results repeatedly obtained from a number of different E. coli K12 strains. The discrepancies include 39 base-pair changes and one addition located predominantly in the proximal portion of the operon. Our data also suggest that neutral and near-neutral mutations do not accumulate to a significant extent in the histidine operon of E. coli strains harbouring strong mutator alleles.